How SSO2 Therapy Works
In SuperSaturated Oxygen (SSO2) Therapy, the patient’s blood is continuously withdrawn using the same access site utilized in the coronary stenting procedure. The TherOx DownStream System, along with hospital saline and oxygen, is employed to create and deliver superoxygenated blood. In the DownStream Cartridge, the patient’s blood is mixed with superoxygenated saline, producing up to 10 times the normal oxygen concentration (1,000 mmHg) normally occurring in the blood. This superoxygenated blood is then returned directly to the coronary artery via the SSO2 Catheter which is placed at the ostium of the left coronary artery. SSO2 Therapy involves a one-time, 60-minute infusion and is conducted in the catheterization laboratory.
SSO2 Mechanism of Action
SSO2 Therapy has demonstrated the ability to:
• improve microvascular flow1,2
• reduce infarct size to recover heart muscle3
SSO2 Therapy works differently than standard oxygen (O2 mask) therapy. Standard O2 therapy works to reach 100% oxygen saturation of the patient’s hemoglobin, the protein in red blood cells responsible for carrying oxygen throughout the body. At a level 7-10x normal, SSO2 delivers high concentrations of dissolved oxygen, at hyperbaric levels, focally to the area of myocardial (heart muscle) damage. This high concentration of dissolved oxygen provides a high concentration gradient of O2 that enables increased diffusive transfer to the oxygen-deficient (ischemic) areas of myocardium. This diffusive transfer of O2 to areas most in need does not depend on blood flow and thus SSO2 can easily access the endothelial cells of capillaries suffering from edema (swelling). SSO2 is able to reverse this edema response in the microvasculature and restore flow, nurturing surrounding heart tissue with oxygenated blood. To view SSO2 in action, view our animation depicting its therapeutic benefit.
1 Bartorelli A, et al. Am Jour of Cardio Drugs. 2003. 3(4); 253-263.
2 Spears JR, et al. ASAIO Jour. 2003 Nov-Dec;49(6):716-20.
3 Stone, et al. Circ Cardiovasc Interv. 2009 Oct; 2:366-375.
Caution: Federal (United States) law restricts this device to sale by or on the order of a physician.
The TherOx DownStream System is indicated for the preparation and delivery of SuperSaturated Oxygen Therapy (SSO2 Therapy) to targeted ischemic regions perfused by the patient’s left anterior descending coronary artery immediately following revascularization by means of percutaneous coronary intervention (PCI) with stenting that has been completed within 6 hours after the onset of anterior acute myocardial infarction (AMI) symptoms caused by a left anterior descending artery infarct lesion.