Key Citations

Below is a list of citations and publication links for information listed on this website.

David SW, et al. Evaluation of intracoronary hyperoxemic oxygen therapy in acute anterior myocardial infarction: The IC-HOT study. Catheter Cardiovasc Interv. 2018;1–9.

Stone GW, et al. Effect of supersaturated oxygen delivery on infarct size after percutaneous coronary intervention in acute myocardial infarction. Circ Cardiovasc Interv. Sep 2009. 2; 366-375.

O’Neill WW, et al. Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT)A Prospective, Randomized Trial of Intracoronary Hyperoxemic Reperfusion After Percutaneous Coronary Intervention. Jour of Am Coll Cardiol. 2007;50; No.5. 397-405.

Warda HM, et al. Effect of intracoronary aqueous oxygen on left ventricular remodeling after anterior wall ST-elevation acute myocardial infarction. Am J Cardiol. 2004;96(1): 22-24.

Bartorelli AL.  Hyperoxemic Perfusion for Treatment of Reperfusion Microvascular Ichemia in Patients with Myocardial Infarction.  Am J Cardiovasc Drugs. 2003;3:253-63.

Spears JR, et al. Aqueous Oxygen Attenuation of Reperfusion Microvascular Ischemia in a Canine Model of Myocardial Infarction. ASAIO Jour. 2003 Nov-Dec;49(6):716-20.

Other Relevant Publications

The list below represents other studies, evaluations and publications related to TherOx SSO2 Technology.

Katukuri N, et al. “Aqueous Oxygen for Treatment of ST- Segment Elevation Myocardial Infarction”. Urgent Interventional Therapies. Nicholas N. Kipshidze, Jawed Fareed, Robert T. Rosen, George D. Dangas, Patrick W. Serruys. John Wiley & Sons, Oxford, 2015; 502-508.

Spears JR, et al. Intracoronary aqueous oxygen perfusion, performed 24 hrs after the onset of postinfarction reperfusion, experimentally reduces infarct size and improves left ventricular function. International J Cardiol. 18 November 2008; 113- 371-5.

Spears JR, et al.  Aqueous oxygen near the homogeneous nucleation limit of water: stabilization with submicron capillaries.  ASAIO Journal. 2006; 52: 186-191.

Spears JR, et al. Aqueous Oxygen Attenuation of Reperfusion Microvascular Ischemia in a Canine Model of Myocardial Infarction.  ASAIO Journal. 2003; 49: 716-720.

Spears JR, et al.  Aqueous Oxygen Hyperbaric Reperfusion in a Porcine Model of Myocardial Infarction.  J Invasive Cardiology. 2002; 14: 160-166.

Dixon SR, et al.  Early recovery of infarct zone function with intracoronary hyperoxemia reperfusion after primary angioplasty for acute myocardial infarction. JACC.2002; 39: 387-92.

Brereton GJ, Crilly RJ, Spears JR.  Nucleation in small capillary tubes.  Chemical Physics. 1998; 230: 253-265.

Spears JR, et al.  Aqueous Oxygen:  a highly O2-supersaturated infusate for regional correction of hypoxemia and production of hyperoxemia.  Circulation. 1997; 96:4385-4391.

Spears JR.  Advances in the Management of Respiratory Failure.  Aqueous preparations of oxygen.  ASAIO Journal. 1996; 42:196-198.